CLSI M02-A10 and M100-S20 Package

Package of 2 Documents: M02-A10 and M100-S20

Performance Standards for Antimicrobial Disk Susceptibility Tests;Approved Standard-Tenth Edition. CLSI document M02-A10 (ISBN 1-56238-716-2)

Susceptibility testing is indicated for any organism that contributes to an infectious process warranting antimicrobial chemotherapy, if its susceptibility cannot be reliably predicted from knowledge of the organism’s identity. Susceptibility tests are most often indicated when the causative organism is thought to belong to a species capable of exhibiting resistance to commonly used antimicrobial agents. A variety of laboratory methods can be used to measure the in vitro susceptibility of bacteria to antimicrobial agents.

In many clinical microbiology laboratories, an agar disk diffusion method is used routinely for testing common, rapidly growing, and certain fastidious bacterial pathogens. Clinical and Laboratory Standards Institute document M02-A10-Performance Standards for Antimicrobial Disk Susceptibility Tests; Approved Standard-Tenth Edition includes a series of procedures to standardize the way disk diffusion tests are performed. The performance, applications, and limitations of the current CLSI-recommended methods are also described.

The supplemental information (M100 tables) presented with this standard represents the most current information for drug selection, interpretation, and quality control using the procedures standardized in M02. These tables, as in previous years, have been updated and should replace tables published in earlier years. Changes in the tables since the previous edition (M100-S18) appear in boldface type and are also summarized in the front of the document.

Performance Standards for Antimicrobial Susceptibility Testing; Twentieth Informational Supplement

The Erratum to M100-S20 of 12 April 2010 is included. The supplemental information presented in this document is intended for use with the antimicrobial susceptibility testing procedures published in the following Clinical and Laboratory Standards Institute (CLSI) approved standards: M02-A10-Performance Standards for Antimicrobial Disk Susceptibility Tests; Approved Standard-Tenth Edition; and M07-A8-Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically; Approved Standard–Eighth Edition